OIL-IN-WATER TYPE EMULSION FOR TOPICAL APPLICATION IN DERMATOLOGY

摘要

1. An oil-in-water emulsion containing at least one topical therapeutic agent selected from corticosteroids, retinoids and vitamin D derivatives, and further comprising: a) a fatty phase; b) from 1% to 15 wt.% a nonionic emulsion system; c) from 1% to 30% by weight of at least one penetration promoting agent; and d) from 5% to 50% by weight of water, characterized in that the content of said fatty phase is from 35% to 50% by weight. The emulsion according to claim 1, in which the fatty phase consists mainly of compounds selected from emollients, waxes and fatty alcohols. The emulsion according to claim 1, in which the non-ionic emulsion system contains at least one non-ionic surfactant having HLB, above about 10, and at least one non-ionic surfactant having HLB, below about 10.4. The emulsion according to any one of paragraphs. 1 or 3, in which the non-ionic emulsion system consists of a pair of surfactants glycerol monostearate / Ceteareth 20.5. The emulsion according to claim 1, wherein the penetration promoting agent is selected from propylene glycol, dipropylene glycol, propylene glycol dipelargonate, lauroglycol, ethoxy glycol, urea, acetone, oleic acid, and mixtures of one or more of them, preferably propylene glycol, dipropylene glycol, preferably - penetration promoting agent is propylene glycol. 6. The emulsion according to claim 1, wherein the therapeutic agent is a compound suitable for the treatment and / or prevention of skin diseases. The emulsion according to claims 1 or 6, in which the therapeutic agent belongs to the class of corticosteroids