METHOD FOR PRODUCING L-AMINO ACID USING THE ENTEROBACTERIACEAE FAMILY POSSESSING AN INCREASED EXPRESSION OF GENES OF THE CASCADE OF THE FORMATION OF FLAGELLS AND CELL MOBILITY

摘要

1. A method for producing an L-amino acid, comprising growing in a nutrient medium a bacterium belonging to the Enterobacteriaceae family and capable of producing an L-amino acid, and isolating said L-amino acid from the culture fluid, characterized in that said bacterium is modified so that expression at least at least one of the genes of the cascade of flagellation and cell motility is enhanced. 2. The method according to claim 1, characterized in that the expression of the gene (s) of the cascade of flagellation and cell motility is enhanced by enhancing the expression of at least one of the genes selected from the group consisting of the gene (s) of the flhDC operon, the yhjH gene, and the fliZ gene , or combinations thereof. 3. The method according to claim 2, characterized in that the expression of the gene (s) of the flhDC operon is enhanced by changing the regulatory region that controls the expression of the specified gene (s). The method according to claim 2, characterized in that the expression of the gene (s) of the flhDC operon is enhanced by increasing the number of copies of the gene (s) of the flhDC operon. The method according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. The method according to claim 1, characterized in that said bacterium is Escherichia coli. 7. The method according to claim 1, characterized in that said bacterium belongs to the genus Enterobacter. The method according to claim 1, characterized in that said bacterium belongs to the genus Pantoea. The method of claim 2, wherein the flhD gene encodes a protein selected from the group consisting of: (A) a protein comprising the amino acid sequence represented as SEQ ID NO: 2; and (B) a protein comprising the amino acid sequence represented as SEQ ID NO: 2, but in which one or more amino acid residues is substituted, deleted, inserted, add