Derivatives of N - (2-azabicyclo 2.1.1 HEX-1-IL) arylmethyl heterobenzamide, their production and their use in therapy

摘要

1. The compound of general formula (I) in which — R represents a hydrogen atom or a group selected from (C — C) alkyl, (C — C) cycloalkyl, benzyl or allyl, optionally substituted with one or more groups selected independently of one another from halogen atoms, (C — C) cycloalkyl, (C — C) alkyl, (C — C) alkoxy, hydroxy; - R represents a phenyl or naphthyl group optionally substituted by one or more substituents selected independently from one another from halogen atoms, (C-C) alkyl, (C-C) alkoxy, halo (C-C) alkyl, hydroxy, halo (C-C) alkoxy, (C-C) alkylthio, (C-C ) alkyl-SO, (C-C) alkyl-SO; - Het is a heteroaryl group; - R is one or more substituents selected from a hydrogen atom, halogen atoms, halo (C-C) alkyl, (C-C) alkyl, (C-C) cycloalkyl, (C-C) cycloalkyl- (C-C) alkyl, (C-C) alkoxy, benzyl, (C-C) alkylthio, (C-C) alkyl-SO, (C-C ) alkyl-SO; in the form of a base or an addition salt with an acid. 2. A compound of general formula (I) according to claim 1, characterized in that R is a hydrogen atom, a benzyl group or an allyl group; R, Het and R are, however, as defined in claim 1, in the form of a base or an addition salt with an acid .3. A compound of general formula (I) according to claim 1, characterized in that R represents a phenyl or naphthyl group optionally substituted by one or more groups selected independently from one another from halogen atoms, (C-C) alkyl, (C-C) alkoxy , halo of (C — C) alkyl; R, Het and R are, as defined in claim 1, in the form of a base or an addition salt with an acid. 4. A compound of general formula (I) according to claim 1, characterized in that Het is indole, thiophene or pyridine; R, R and R are, however, as defined in claim 1, in the form of a base or a salt of