PRESENTED IN Salmonella enterica N-GLYCAN FROM C.jejuni AND ITS DERIVATIVES

摘要

1. Salmonella enterica, characterized in that it contains at least one pgl operon from Campylobacter jejuni or a functional derivative thereof and presents at least one Campylobacter jejuni N-glycan or derivative of such N-glycan on its cell surface. 2. Salmonella enterica according to claim 1, selected from the group consisting of Salmonella typhimurium, enteriditis, heidelberg, gallinorum, hadar, agona, kentucky and infantis, more preferably from strains of Salmonella enterica serovar Typhimurium. Salmonella enterica according to any one of claims 1 or 2, containing at least one pgl operon, in which one or more genes for bacillosamine biosynthesis are inactivated by a mutation and / or partial or complete deletion, preferably a partial and / or complete deletion of pgl D genes , E, F, G. 4. Salmonella enterica according to any one of claims 1 or 2, containing at least one pgl operon in which the pglB gene product is inactivated by mutation and / or deletion. Salmonella enterica according to any one of claims 1 or 2, in which at least one N-glycan has the formula (I) GalNAc-a1,4-GalNAc-a1,4- [Glc-β-1,3] GalNAc- a1,4-Gal-NAc-a1,4-GalNAc-a1,3-Bac, where you (also called bacillosamine) is 2,4-diacetamido-2,4,6-tridesoxy-D-glucopyranose. 6. Salmonella enterica according to any one of claims 1 or 2, in which at least one N-glycan derivative has the formula (II) GalNAc-a1,4-GalNAc-a1,4- [Glc-β-1,3] GalNAc -a1,4-Gal-NAc-a1,4-GalNAc-a1,3-GlcNAc. 7. Salmonella enterica according to any one of claims 1 or 2, in which the N-glycan (s) or derivative (s) is associated with at least one homologous or heterologous Salmonella polypeptide that is carried and presented on the cell surface, and preferably associated with at least one polypeptide containing at least one HZS / T consensus sequence, more preferably D / EXNZS / T (SEQ ID NO: 1), where X and Z can be any naturally occurring amino acid