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首页> 外国专利> FLUORINE CONTAINING SUBSTITUTED 5- 2- (PYRID-3-IL) -ETHYL -2,3,4-TETRAHYDRO-1H-PYRIDO 4,3-b INDOLES, THEIR CHLOROHYDRATES AND BROMHYDRATES AS A LOW REDUCER NERVOUS SYSTEM, PHARMACOLOGICAL MEANS ON THEIR BASIS AND METHOD OF ITS APPLICATION

FLUORINE CONTAINING SUBSTITUTED 5- 2- (PYRID-3-IL) -ETHYL -2,3,4-TETRAHYDRO-1H-PYRIDO 4,3-b INDOLES, THEIR CHLOROHYDRATES AND BROMHYDRATES AS A LOW REDUCER NERVOUS SYSTEM, PHARMACOLOGICAL MEANS ON THEIR BASIS AND METHOD OF ITS APPLICATION

机译：氟取代的5- [2-（PYRID-3-IL）-乙基] -2,3,4-四氢-1H-吡咯[4,3-b]吲哚，其氯酸盐和溴酸盐是一种低还原剂神经系统，药理学依据及其应用方法

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1. Fluorine-substituted 5- [2- (pyrid-3-yl) ethyl] -2,3,4-tetrahydro-1H-pyrido [4,3-b] indoles, their hydrochlorides and bromohydrates, of the general formula 1 as agents for reducing uncontrolled aggregation of proteins in the nervous system (I) where R = R = R = H, Me or R + R = -CH-CH-; R = H, (CC) alkyl, (CC) alkenyl, (CC) alkynyl , (CC) alkoxy (C — C) alkyl, [F, Cl, Br, NO, (C — C) alkyl, (C — C) alkoxy, acyl, (C — C) alkylsulfonyl, (C — C) alkoxycarbonyl substituted ] aryloxy (С-С) alkyl, (CC) cycloalkyl, [F, Cl, Br, NO, (С-С) alkyl, (С-С) alkoxy, acyl, (С-С) alkylsulfonyl, (С-С ) alkoxycarbonyl substituted] aryl, heteryl, (C — C) alkylsul phonyl, (C — C) alkoxycarbonyl, (C — C) acyl, [F, Cl, Br, NO, (C — C) alkyl, (C — C) alkoxy, acyl, (C — C) alkylsulfonyl, (C -C) alkoxycarbonyl substituted] aroyl, heteroil, N, N-dialkylcarbamoyl, N, N-dialkylaminosulfonyl; R, R, R, R = H, F, Cl, Br, CN, OH, CF, CFO, CHFO, NO, ( CC) alkyl, (CC) cycloalkyl, (CC) alkoxy, [F, Cl, Br, NO, (C — C) alkyl, (C — C) alkoxy, acyl, (C — C) alkylsulfonyl, (C — C ) alkoxycarbonyl substituted] aryl, [F, Cl, Br, NO, (C-C) alkyl, (C-C) alkoxy, acyl, (C-C) alkylsulfonyl, (C-C) alkoxycarbonyl-substituted] aryloxy, (Me, Cl , Br - substituted) pyridyl, (C — C) alkylsulfonyl, (C — C) alkoxycarbonyl, (C — C) acyl, [F, Cl, Br, NO, ( C-C) alkyl, (C-C) alkoxy, acyl, (C-C) alkylsulfonyl, (C-C) alkoxycarbonyl-substituted] aroyl, N, N-dialkylcarbamoyl, N, N-dialkylaminosulfonyl; R = F, 2F, CHF , CClF, CF; X = no, Cl, Br. 2. A pharmacological agent for reducing uncontrolled aggregation of proteins in the nervous system, containing an active principle and a pharmaceutically acceptable carrier, characterized in that it contains an effective amount of a compound of formula (1) as an active principle. 3. A method of reducing the uncontrolled aggregation of proteins in the nervous system, which consists in the introduction of pharmacol to the patient
机译：1.通式1的氟取代的5- [2-（吡啶-3-基）乙基] -2,3,4-四氢-1H-吡啶[4,3-b]吲哚，其盐酸盐和溴水合物作为减少神经系统中蛋白质不受控制的聚集的药物（I），其中R = R = R = H，Me或R + R = -CH-CH-; R = H，（CC）烷基，（CC）烯基，（CC）炔基，（CC）烷氧基（CC）烷基，[F，Cl，Br，NO，（CC）烷基，（CC ）烷氧基，酰基，（CC）烷基磺酰基，（CC）烷氧基羰基取代的]芳氧基（С-С）烷基，（CC）环烷基，[F，Cl，Br，NO，（С-С）烷基， С-С）烷氧基，酰基，（С-С）烷基磺酰基，（С-С）烷氧基羰基取代]芳基，杂芳基，（CC）烷基磺酰基，（CC）烷氧基羰基，（CC）酰基，[ F，Cl，Br，NO，（CC）烷基，（CC）烷氧基，酰基，（CC）烷基磺酰基，（C-C）烷氧基羰基取代]芳酰基，杂原子，N，N-二烷基氨基甲酰基，N ，N-二烷基氨基磺酰基; R，R，R，R = H，F，Cl，Br，CN，OH，CF，CFO，CHFO，NO，（CC）烷基，（CC）环烷基，（CC）烷氧基，[F，Cl，Br， NO，（CC）烷基，（CC）烷氧基，酰基，（CC）烷基磺酰基，（CC）烷氧基羰基取代的]芳基，[F，Cl，Br，NO，（CC）烷基， CC）烷氧基，酰基，（CC）烷基磺酰基，（CC）烷氧基羰基取代的]芳氧基，（Me，Cl，Br-取代的）吡啶基，（CC）烷基磺酰基，（CC）烷氧基羰基，（CC）酰基，[F，Cl，Br，NO，（CC）烷基，（CC）烷氧基，酰基，（CC）烷基磺酰基，（CC）烷氧基羰基取代的]芳酰基，N，N-二烷基氨基甲酰基，N，N-二烷基氨基磺酰基; R = F，2F，CHF，CClF，CF; X =不，Cl，Br。 2.一种用于减少神经系统中蛋白质不受控制的聚集的药理剂，其包含活性成分和药学上可接受的载体，其特征在于，其包含有效量的式（1）化合物作为活性成分。 3.减少神经系统中蛋白质不受控制的聚集的方法，该方法包括将Pharmaccol引入患者

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