KIT FOR PRELIMINARY ACTION DIRECTION, METHOD AND MEANS USED IN IT

摘要

1. A kit for guided medical imaging and / or clinical medicine, comprising at least one pre-guide probe and at least one effector probe, where the pre-guide probe contains a primary guide fragment and a first bioorthogonal reactive group, and where the effector probe contains an effector fragment, such as a label or pharmaceutically active compound, and a second bioorthogonal reactive group, where any of the first and second bioorthogonal reaction of particular groups is a dienophile, and the other of the first and second bioorthogonal reactive groups is a diene, where the dienophile is a strained 8-membered cyclic dienophile corresponding to the formula (1): where each R independently represents H or in at least six cases a substituent, selected from the group consisting of alkyl, O-alkyl, S-alkyl, F, Cl, Br, I, SO, NO, NR'R ", with R 'and R" each independently represent H or alkyl, C (= O) Oalkyl, C (= O) Oaryl, CONR'R ", wherein R 'and R" are each independently H, aryl and whether alkyl, OCO alkyl, OCO aryl, NR'CO alkyl, wherein R 'represents H or alkyl, NR'CO aryl, wherein R' represents either alkyl, NR'C (= O) O alkyl, wherein R 'represents H or alkyl, NR'C (= O) Oaryl, wherein R 'represents H or alkyl, OCONR'alkyl, wherein R' represents H or alkyl, OCONR'aryl, wherein R 'represents H or alkyl, NR'CONR "alkyl, moreover, R 'and R "each independently represent H or alkyl, NR'CONR" aryl, and R' and R "each independently represent H or alkyl, NR'CSNR" alkyl, with R 'and R " each independently represent H or alkyl, and NR'CSNR