METHOD coulometric determination of water content in the tablet mass

摘要

FIELD: medicine.;SUBSTANCE: invention describes a method for measuring the water content in tablet mass in tablet production by coulometric titration which is based on a reaction of water of an examined sample with a iodine electrically generated coulometric titrant which is formed by electrolysis of organic or non-organic iodide (e.g. CH₃I or KI), being a part of a ground electrolyte at constant current 50 mA for a period of time determined by biopotentiometry and shown by an end-point titre achieved; the water content (X, g) in an aliquot of the examined sampled is calculated by formula, and simultaneously water is measured in a solvent, and common formulas are used to measure the water content in the tablet mass.;EFFECT: method is characterised by expressivity, experimental simplicity, sensitivity and accuracy.;2 tbl, 1 dwg, 1 ex