USE OF PPAR DELTA LIGANDS FOR TREATMENT OR PREVENTION OF INFLAMMATION OR DISEASES ASSOCIATED WITH METABOLISM / ENERGY PRODUCTION

摘要

1. A method of treating lung diseases selected from the group consisting of chronic obstructive airways disease (COAD), chronic obstructive pulmonary disease (COPD), adolescent asthma, emphysema or adolescent asthma, comprising administering a compound of formula (I) or a salt thereof : where R is phenyl, naphthyl, pyridyl, thienyl, furyl, quinolyl or benzothienyl, any of which may have substituents selected from the group consisting of C1-6 alkyl, C1-6 alkyl containing halogen, C1-4 alkoxy, C1-4 alkoxy containing halogen n, Calkenyl, Calkynyl, halogen, Cacyl, benzoyl, hydroxyl, nitro, amino, phenyl and pyridyl; R is C 1-6 alkyl, C 1-6 alkyl containing halogen, C 2-6 alkenyl, C 2-6 membered cycloalkyl, 3-7 membered C 1-6 alkyl cycloalkyl, or C1-6alkyl substituted with phenyl, naphthyl or pyridyl, any of which may have substituents selected from the group consisting of C1-6alkyl, C1-6alkyl containing halogen, C1-6 alkoxy, C1-4 alkoxy, containing halogen, C1-6alkenyl, C1-6alkyl, halogen, 1-4 acyl, benzoyl, hydroxyl , nitro, amino, phenyl and pyridyl; A represents co oxygen, sulfur or NR, where R represents hydrogen or C 1-6 alkyl; X represents a C 1-6 alkylene chain which may have substituents selected from the group consisting of C 1-6 alkyl, C 1 alkoxy and hydroxyl, and which may contain a double bond; Y represents C (= O), C (= N-OR), CH (OR), CH = CH, CC, or C (= CH), where each of R and R represents hydrogen or C1-6 alkyl; each of R, R and R represents hydrogen, C1-6 alkyl, Calkyl containing halogen, Calkoxy, Calkoxy containing halogen, Calkenyl, Calkynyl, halogen, Cacyl, benzoyl, hydroxyl, nitro, amino, phenyl or pi