VACCINES BASED ON SWINE VIRUS Torque teNO AND METHODS FOR DIAGNOSTIC OF INFECTIONS CAUSED BY THIS VIRUS

摘要

1. Infectious pig Torque teNO virus (PTTV) nucleic acid molecule, comprising an infectious PTTV nucleic acid molecule that contains at least one copy of the genomic sequence of at least 85% of the homologous genomic sequence selected from the group consisting of PTTV1a -VA, PTTV1b-VA, PTTV2b-VA and PTTV2c-VA. 2. The infectious nucleic acid molecule according to claim 1, wherein at least one copy of the genomic sequence is at least 95% homologous to the genomic sequence selected from the group consisting of PTTV1a-VA, PTTV1b-VA, PTTV2b-VA and PTTV2c-VA. 3. The infectious nucleic acid molecule according to claim 1, wherein the genomic sequence is selected from the sequences represented by SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12.4. A biologically functional plasmid or viral vector containing the infectious nucleic acid molecule of Claim 3.5. The biologically functional plasmid or viral vector according to claim 4, containing more than one copy of the infectious nucleic acid molecule. A suitable host cell transfected with a vector containing the infectious nucleic acid molecule according to 4.7. The avirulent infectious PTTV produced by cells containing the infectious nucleic acid molecule of claim 6.8. A vaccine containing a non-toxic physiologically acceptable carrier and an immunogenic amount of an element selected from the group consisting of: (a) a nucleic acid molecule containing at least one copy of the genomic sequence of at least 80% homologous genomic sequence selected from the group consisting of from PTTV genotypes or subtypes of PTTV1a-VA, PTTV1b-VA, PTTV2b-VA or PTTV2