Identification and quantification of biomarkers for risk of preterm birth ASSESSMENT

摘要

1. A method for assessing the risk of preterm labor in a pregnant subject comprising: (a) identifying a combination of the first biomarker and second biomarker present in a biological sample from the subject, wherein the first biomarker includes the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2 , SEQ ID NO: 3, or any combination thereof, and the second biomarker is a protein comprising kortikotrofin-releasing factor, defensin, ferritin, lactoferrin complex of thrombin - antithrombin, receptor type 1 factor α tumor necrosis or any combination thereof, and (b ) about amount-determination of the first and second biomarkers in a biological obraztse.2. A method according to claim 1, wherein step (b) comprises determining the relative content of the first and second biomarkerov.3. A method according to claim 2, further comprising: comparing the content of the first and second biomarker in a biological sample from a control concentration of said first and second control biomarkers in a biological sample originating from a subject who does not have any premature labor, for the establishment of an increased risk of preterm rodov.4. A method according to claim 3, wherein the determination of increased risk of preterm delivery include determining that the contents of at least one peptide in a biological sample is significantly less than the control concentration of at least one peptide in a control biological obraztse.5. A method according to claim 2, further comprising: comparing the content of the first and second biomarker in a biological sample from a control concentration of test molecule in a biological sample from the subject for the establishment of an increased risk of preterm p