RECOMBINANT VACCINE BASED ON PARAMYXOVIRUSES OF BIRDS AND METHOD FOR PREPARING AND USING IT

摘要

1. A composition or vaccine comprising (i) a recombinant APMV viral vector and (ii) a pharmaceutically or veterinarily acceptable carrier. The composition or vaccine of claim 1, wherein the APMV is APMV-8, APMV-2, APMV-4, or APMV-6.3. The composition or vaccine of claim 1, wherein the APMV viral vector comprises a polynucleotide having at least 90% sequence identity with a polynucleotide having the sequence shown in SEQ ID NO: 1, or a polynucleotide complementary to a polynucleotide having at least at least 90% sequence identity with a polynucleotide having the sequence shown in SEQ ID NO: 1.4. A composition or vaccine according to any one of claims 1 to 3, wherein the APMV viral vector further comprises an isolated polynucleotide encoding an antigen, and where the polynucleotide is inserted into an non-essential part of the APMV genome. 5. The composition or vaccine according to claim 3, wherein the non-essential site is selected from sites including a non-translated portion located above the open reading frame NP, intergenic sections between two open reading frames of the APMV genome, and a non-translated portion located below the open reading frame L.6. A method for producing a recombinant APMV viral vector, which comprises introducing an isolated polynucleotide into the non-essential part of the APMV genome into the APMV genome. The method of claim 6, wherein the APMV is APMV-8, APMV-2, APMV-4, or APMV-6.8. The method of claim 6, wherein the APMV comprises a polynucleotide having at least 90% sequence identity with a polynucleotide having the sequence shown in SEQ ID NO: 1, or a polynucleotide complementary to a polynucleotide having at least 90% identity of the aftermath