DOSAGE FORM OF ORALLY DISINTEGRATING TWO-PIECE TABLET

摘要

FIELD: medicine.;SUBSTANCE: invention refers to a dosage form containing a disintegrating piece of the tablet and a solid caramelised piece, wherein: (i) the disintegrating piece of the tablet contains at least one pharmaceutically active ingredient, and (ii) the solid caramelised piece covers at least 20% of a surface of the disintegrating piece of the tablet, and wherein a disintegration time of the solid caramelised piece is at least ten times more than that of the disintegrating piece of the tablet. The pharmaceutically active ingredient is specified in a group of analgesics, anti-inflammatory and antipyretic agents, agents for treating gastrointestinal tract, neuromuscular blocking agents, anaesthetics, antihistaminic agents, decongestants, antitussive and expectorant drugs. The mass ratio of the disintegrating piece of the tablet and the solid caramelised piece makes 10:90 to 60:40. Preferentially, the disintegrating piece of the tablet as the pharmacologically active ingredient contains ibuprofen, while the caramelised piece contains ambroxol.;EFFECT: dosage form under the invention is applicable for treating such diseases as pharyngalgia, congestions and cough.;29 cl, 9 tbl, 9 ex