METAL CHELATES HAVING PERFLUORINATED PEG RADICAL, METHODS FOR PRODUCTION THEREOF AND USE THEREOF

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to metal chelates of formula I: where PEG-Pf denotes a perfluorinated PEG radical having 4-30 carbon atoms, including a) at least one perfluorinated PEG radical of formula XXI: CF₃-(CF₂)_n"'[-O-(CF₂)₂]_m"'-O-(CF₂)-, where n"' denotes an integer between 0 and 6, m''' denotes an integer between 1 and 14; linker denotes a linker group which links the PEG-Pf radical with the skeleton; skeleton denotes a trivalent radical which is a nitrogen-containing radical selected from amino acids having a side functional chain, an alkylene diamine radical and derivatives thereof, nitrogen and 3,5-diaminobenzoic acid, K denotes a chelate radical consisting of a chelating radical and at least one equivalent metal ion with atomic number of 57-83. Also disclosed is use of metal chelates to produce contrast agents.;EFFECT: invention enables to obtain contrast agents for MRT, having good imaging properties and high transferability.;9 cl, 3 dwg, 4 tbl, 37 ex