METHOD FOR REDUCING MAMMALIAN ANXIETY LEVEL, METHOD FOR REDUCING ANXIETY LEVEL, USE OF DELTA-OPIOID RECEPTOR ANTAGONISTS NOT PENETRATING THROUGH BRAIN-BLOOD BARRIER FOR PREPARING ANXIOLYTIC AGENTS

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: present group of inventions refers to medicine, namely neurology and therapy, and concerns reducing mammalian anxiety level. That is ensured by delta-opioid receptor antagonists not penetrating through brain-blood barrier such as M-154129; ICI 154,129;N,N-Di(2-propenyl)-L-Tyr-N-[2- [[(S)-2-[[(S)-l-carboxy-3-methylbutyl]amino]-2-oxo-l- benzylethyl]thio]ethyl]-Gly-NH2.;EFFECT: provided anxiolytic effect ensured by reciprocity of the peripheral and central endogenic opioid system that causes activation of the delta opioid system in the central nervous system by suppression of peripheral delta-opioid receptors in stomach.;3 cl, 3 ex, 3 tbl