METHOD FOR INCREASING STREPTOMYCIN ACTIVITY ON STREPTOMYCIN-RESISTANT TUBERCULOSIS MYCOBACTERIA

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to pharmaceutical industry and represents a method for increasing streptomycin activity on streptomycin-resistant tuberculosis mycobacteria consisting in the fact that streptomycin detoxification and polymerisation are conducted at first in 0.15±0.05% glutaric aldehyde at 38±40°C for 2-3 days, and then in 0.1% aethonium or 0.1% alkyldimethylbenzene ammonium chloride or 0.1% Biopague D at 38-40°C for 2-3 days at 100-150 mg/ml of the antibiotic.;EFFECT: invention provides higher efficacy and lower toxicity of the antibiotics.;3 ex