METHOD FOR DETECTING NITROFURAN, PYRAZOLE, ISONICOTINIC ACID, THIOAMINO ACID DERIVATIVES IN DOSAGE FORMS

摘要

FIELD: medicine.;SUBSTANCE: invention describes a method for detecting nitrofuran, pyrazole, isonicotinic acid, thioamino acid derivatives in dosage forms consisting in preliminary transforming the analysed preparation into a liquid form, placing it in a cell containing a certain amount of generated iodine prepared by exposing the reaction mixture consisting of 0.5 M potassium iodide, a buffer solution and a sentitiser - sodium eosinate, to a stabilised light source, measuring current intensity in the cell, and once current stability reached, air-blowing the solution in the cell for 1-2 min, exposing to light and measuring a generation time for iodine loss compensation, determining an amount of the analysed preparation as shown by a calibration diagram of current intensity and iodine generation time.;EFFECT: simplified method, reduced length of the analysis, higher accuracy and wider detection limits of organic substances in the pharmaceutical preparations.;2 ex, 2 tbl, 2 dwg