C1 PROTEIN 2 CHAIN OF CARTILAGE INTERMEDIATE LAYER AND USE THEREOF FOR DIFFERENTIAL DIAGNOSIS OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS AND NON-PATHOLOGICAL STATES

摘要

FIELD: medicine.SUBSTANCE: what is presented is a method for differentiation of osteoarthritis, rheumatoid arthritis, and non-pathological states in a sample, including the measurement of the concentration of the peptide of a C1 protein 2 chain of the cartilage intermediate layer (CILP-2). The high level of the C1 protein 2 chain CILP-2 compared with rheumatoid arthritis and the normal state indicates that the patient has osteoarthritis. What is also presented is a peptide for differentiation of osteoarthritis and rheumatoid arthritis and non-pathological states, comprising SEQ ID NO:1. There are presented antibodies immunoreactive to the mentioned peptide, and a kit containing the antibodies and the analysis regulation.EFFECT: effective agents and methods for differentiation of osteoarthritis, rheumatoid arthritis and non-pathological states by the increase of the concentration of the C1 protein 2 chain of the cartilage intermediate layer in the sample.7 cl, 2 dwg, 4 ex