METHOD FOR PREDICTION OF CLINICAL EFFECTIVENESS OF RHEUMATOID ARTHRITIS BY TNF-ALPHA MONOCLONAL ANTIBODIES ON BASIS OF ALLELIC POLYMORPHISM OF TNF GENE PROMOTER

摘要

FIELD: medicine.;SUBSTANCE: what is presented is a method for prediction the efficacy of the anti-TNF therapy in the patients with rheumatoid arthritis on the basis of genetic typing the polymorphisms of TNF-alpha proinflammatory cytokine. The allelic polymorphism of the TNF-alpha gene promoter is studied in position 857. If the heterozygous state (genotype - 857ST) or the homozygous T allele carriers (genotype - 857TT) is identified, a high probability of the successful infliximab therapy is predicted. If identifying the homozygous allele C carrier in position - 857 of the TNF-alpha gene promoter (genotype - 857SS), a high probability of the failed infliximab therapy is predicted.;EFFECT: invention enables the rapid and effective prediction of the clinical outcome of the anti-TNF therapy in the patients with rheumatoid arthritis by one polymorph position.;2 tbl, 1 ex