USING SEQUENCE CODING C-TERMINAL HEAVY CHAIN DOMAIN OF TETANUS TOXIN AS THERAPEUTIC AGENT

摘要

FIELD: medicine.SUBSTANCE: group of inventions refers to medicine and concerns using a polynucleotide which contains a sequence coding a C-terminal heavy subunit domain of tetanus toxin (HcTeTx), for treating amyotrophic lateral sclerosis (ALS), as well as using a polynucleotide which contains a C-terminal of a heavy subunit of tetanus toxin (HcTeTx), for treating the above disease.EFFECT: group of inventions provides relieving the ALS symptoms ensured by introducing an isolated non-toxic fragment of tetanus toxin (HcTeTx or a fragment thereof) or the polynucleotide coding the above fragment.17 cl, 4 ex, 11 dwg, 2 tbl