METHOD OF TREATING IMMUNE DYSFUNCTION, SUCH AS GRAFT-VERSUS-HOST OR HOST-VERSUS-GRAFT DISEASE

摘要

FIELD: medicine.;SUBSTANCE: group of inventions refers to medicine, namely to transplantology, and may be used for treating graft-versus-host disease (GVHD). That is ensured by introducing pluripotent cells, other than embryo stem cells, embryo germ-line cells, germ-line cells into an individual. The cells may differentiate in one cell type of any of at least two embyo lines - endodermal, ectodermal and mesodermal. The cells express telomerase; they are allogenic for the individual and promote the negative immune response. The group of inventions also refers to the above cells which are grown and processed during 10 to 40 cycles of cell duplication in a culture, and then specific markers (oct-3/4, rex-1 and rox-1) are expressed.;EFFECT: method enables using the pluripotent mature precursor cells additionally for immune suppression for transplantation.;21 cl, 10 dwg, 12 ex