Producing comb polymers involves providing polyols as backbone, and reacting polyol with amino, ammonium, carboxyl, sulfonyl, sulfonic acid and/or phosphate group-containing compound to form negatively and/or positively charged side chains

摘要

Producing comb polymers comprises (a) providing polyols as backbone, (b) partially reacting the polyol with an amino group-containing compound, an ammonium group-containing compound, a carboxyl group-containing compound, a sulfonyl group-containing compound, a sulfonic acid group-containing compound and/or a phosphate group-containing compound to form negatively charged and/or positively charged side chains, and (c) reacting the polyols, provided with negatively charged and/or positively charged side-chains, with hydroxycarboxylic acids and/or its esters to form hydrophobic side-chain. Producing comb polymers comprises (a) providing polyols as backbone, (b) partially reacting the polyol with an amino group-containing compound, an ammonium group-containing compound, a carboxyl group-containing compound, a sulfonyl group-containing compound, a sulfonic acid group-containing compound and/or a phosphate group-containing compound to form negatively charged and/or positively charged side chains, and (c) reacting the polyols, provided with negatively charged and/or positively charged side-chains, with hydroxycarboxylic acids and/or its esters to form hydrophobic side-chain, where the hydroxycarboxylic acids are present as monomers, dimers, oligomers and/or polymers, and the step (c) takes place in the form of a solution polymerization. An independent claim is included for a colloidal nanoparticle, comprising the water-soluble comb polymer and/or an active substance consisting of proteins, preferably insulin, calcitonin, erythropoietin, granulocyte stimulating factor, fibroblast stimulating factor or parathyroid hormone, DNA and its derivatives, somatostatin, cyclosporine and/or prostanoids.