NON-INTEGRATIVE CHIMERIC LENTIVIRAL GENOMES AS INNOVATIVE VACCINES AGAINST HIV-1

摘要

The present invention relates to nucleic acids comprising non-integrative chimeric retroviral genomes comprising the 5 'and 3' repeat terminal sequences (STR) of the goat lentivirus: arthritis-encephalitis caprine virus (VAEC) or another retrovirus not integrating into human cells and at least one viral gene from another retrovirus. The invention also relates to a vector comprising such a nucleic acid, an immunogenic or vaccine composition comprising said vector or nucleic acid, and their use for the treatment and / or prevention of infection by a retrovirus or a disease induced by a pathogen.