MICRO-RNA FOR REGULATING MUSCLE CELL PROLIFERATION AND DIFFERENTIATION

摘要

PROBLEM TO BE SOLVED: To provide a method for treating muscle injury in a subject by promoting muscle cell proliferation and differentiation, and to provide a pharmaceutical composition therefor.SOLUTION: A method comprises administering to a muscle injury site in a subject an effective amount of a miRNA or a vector encoding the miRNA or an inhibitor of miRNA, wherein the miRNA is targeted to a gene in a myocyte at the muscle injury site. The inhibitor of miRNA is capable of hybridizing to a target miRNA, the target miRNA is selected from the group consisting of miR-1, miR-133, miR-206, miR-208, miR-22, miR-26, miR-29, miR-30, miR-128, miR-143, and miR-145.