METHODS AND COMPOUNDS FOR INDUCING APOPTOSIS BY STIMULATING ER STRESS

摘要

PROBLEM TO BE SOLVED: To provide a novel method for inducing apoptosis.SOLUTION: Apoptosis is induced by inducing or aggravating stress in cell endoplasmic reticulum (ER) by using pyrazolyl benzenesulfonamide derivative represented by celecoxib represented by the following formula. Preferably, celecoxib is used in combination with bortezomib, wherein Ris CF; Rand Rare methyl; R, R, R, and R-Rare a hydrogen atom; and Ris 3-aminophenyl.