In accordance with the present invention, embodiments provide methods and systems for assessing regional cardiac function and dyssynchrony from imaging modalities using motion of intracardiac characteristics of the heart. In this method and system, an imaging modality, such as a CT scanner, is used to obtain an image sequence, which is then processed using a computer program. The computer program is configured to create an intracardiac mesh formed from triangular components that represent at least a region of interest in the subject's heart. A displacement map can be modeled by tracking the motion of the stored topological characteristics on this intracardiac mesh at at least two time points. The displacement map can be further analyzed to determine local functional metrics such as, for example, SQUEEZ, myocardial strain, torsion, etc., and the displacement map can also be It can be used to create a visual indication of the function of the subject's heart.
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