Mutant formate dehydrogenase, gene encoding the same, and method for producing NADH

摘要

By using the formate dehydrogenase showing a specific activity as high as it can not be predicted from the conventional knowledge, to improve the durability of the formate dehydrogenase. To introduce specific amino acid substitutions for the formate dehydrogenase of Akakabi origin. In order to exhibit excellent durability remarkably in comparison with formate dehydrogenase of wild type, mutant formate dehydrogenase is able to improve the productivity of NADH which is manufactured by using this mutant formate dehydrogenase possible.