Host cells and methods for producing a disulfide bond containing protein

摘要

Bacillus that is genetically modified with a nucleic acid encoding such as TrxA activity decreased, staphylococcal Kokaru and cytoplasmic reductase activity was reduced, such as (Staphylococcal) oxidase, a heterologous oxidase invention (Bacillus) host cells I provide. Method of producing a disulfide bond containing proteins using the host cells of the invention, and methods of improving folding of disulfide bond containing proteins such using the host cells of the invention present invention. None [Selection Figure]