Substituted indeno 1,2-B indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutics, cytostatics and diagnostics

摘要

Synthesis of novel substituted indeno[1,2-b]indole derivatives of the type of 5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-diones and 5H-indeno[1,2-b]indole-6,9,10-triones, which show pronounced inhibition of the human protein kinase CK2, and the use thereof as active ingredients in medicaments and/or drug products in particular for the treatment of neoplastic diseases.