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Tripodal ligands with coordination motifs κ2-BH2 or κ3-BH3 related to biomolecular applications of organometallic compound complexes
Tripodal ligands with coordination motifs κ2-BH2 or κ3-BH3 related to biomolecular applications of organometallic compound complexes
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机译:与有机金属化合物配合物的生物分子应用有关的具有配位基序κ2-BH2或κ3-BH3的三脚架配体
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摘要
The present invention relates to a compound for use as a chelator in the radioactive labeling of biomolecules with metal tricarbonyl complexes, which compound has the general Formula (I) wherein M is a monovalent cation, such as Li, Na, K, Tl, Rb, Cs or an alkyl ammonium; R1 is H, alkyl, aryl or a biomolecule; R2 is H or a pendant arm, said pendant arm optionally comprises a biomolecule, with the proviso that when R1 is H, R2 is not H or COOH, and when R1 is alkyl or aryl, R2 is not H.
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机译:本发明涉及在金属三羰基配合物的放射性标记生物分子中用作螯合剂的化合物,该化合物具有通式(I),其中M是一价阳离子,例如Li,Na,K,Tl,Rb ,Cs或烷基铵; R1是H,烷基,芳基或生物分子; R 2是H或悬垂臂,所述悬垂臂任选地包含生物分子,条件是当R1是H时,R2不是H或COOH,而当R1是烷基或芳基时,R2不是H。
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