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Production method of the insoluble carrier particles, insoluble carrier particles, measuring reagent, sample analysis tool and turbidimetric immunoassay
Production method of the insoluble carrier particles, insoluble carrier particles, measuring reagent, sample analysis tool and turbidimetric immunoassay
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机译:不溶性载体颗粒的生产方法,不溶性载体颗粒,测量试剂,样品分析工具和浊度免疫测定
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摘要
The present invention provides a measurement reagent that is capable of suppressing nonspecific aggregation even when the amount of antibody to be carried is increased, and is capable of measuring in a wide measurement concentration range with high measurement sensitivity; an immunoturbidimetric assay using the same; and a method of producing thereof. A method of producing an insoluble carrier particle of the present invention is a method of producing an insoluble carrier particle carrying an antibody or an antigen on a particle surface thereof. The method includes a sensitization reaction processes in which the antibody or the antigen is brought into contact with the insoluble carrier particle in the presence of an amino acid with a charged polar side chain in a sensitization reaction solution. The insoluble carrier particles obtained by the producing method of the present invention show favorable dispersibility because nonspecific aggregation is suppressed. As can be seen from Examples 1-1 to 1-4 in FIG. 3 , when the insoluble carrier particles are applied to measurement by an immunoturbidimetric assay, a wide measurement concentration range and high measurement sensitivity can be achieved.
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