首页> 外国专利> SMALL CHEMICAL COMPOUND WHICH PROMOTES INDUCTION OF DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS AND METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS USING SAID SMALL CHEMICAL COMPOUND

SMALL CHEMICAL COMPOUND WHICH PROMOTES INDUCTION OF DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS AND METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS USING SAID SMALL CHEMICAL COMPOUND

机译:促进所述干细胞向胰岛素生产细胞分化诱导的小化学化合物和利用所述的小​​化学化合物促进干细胞向胰岛素生产细胞诱导分化的方法

摘要

A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of ES cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of ES cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells. Another purpose of the present invention is to provide the thus-induced insulin-producing cells. Provided are: an agent for promoting induction of the differentiation of stem cells derived from a mammal into insulin-producing cells, which contains a compound that is selected from the group consisting of dopamine metabolism inhibitors, serotonin metabolism inhibitors, acetylchotine, acetylcholine degrading enzyme inhibitors and acetylcholine receptor activators; and a method for inducing differentiation using the agent for promoting induction of differentiation.
机译:本发明的目的是提供一种小的化合物,其特别促进诱导ES细胞分化为产生胰岛素的细胞。本发明的另一个目的是提供:使用该化合物诱导ES细胞分化为胰岛素产生细胞的方法;促进诱导分化为胰岛素产生细胞的药剂。本发明的另一个目的是提供由此诱导的产生胰岛素的细胞。提供:促进诱导哺乳动物来源的干细胞向胰岛素产生细胞分化的试剂,其包含选自多巴胺代谢抑制剂,5-羟色胺代谢抑制剂,乙酰胆碱,乙酰胆碱降解酶抑制剂的化合物和乙酰胆碱受体激活剂;以及使用促进分化诱导剂的诱导分化的方法。

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