OPTIMIZED AND HIGH THROUGHPUT COMPARISON AND ANALYTICS OF LARGE SETS OF GENOME DATA

摘要

A method, computer program product and system for reconciling a plurality of surprisal data sets of a genetic sequence of an organism being generated from a surprisal data reference genome using a base reference genome. If the base reference genome is not the surprisal data reference genome indicated in the surprisal data set, the surprisal data reference genome is retrieved and compared to the base reference genome to obtain reference genome differences. If a starting location of an instance of the surprisal data set is present in the reference genome differences, the nucleotides of the instance of the surprisal data are compared to the nucleotides of the reference genome difference. If the nucleotides of the instance of the surprisal data are the same as the nucleotides of the reference genome difference, the instance of surprisal data is removed from the surprisal data set.