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MODULATION OF THE SONIC HEDGEHOG PATHWAY AND USES THEREOF
MODULATION OF THE SONIC HEDGEHOG PATHWAY AND USES THEREOF
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机译:声音刺猬通路的调制及其用途
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摘要
A method for modulating Sonic hedgehog (Shh)-mediated signalling and proliferation based on agents that modulates the binding of GAS1, BOC and/or CDON to Ptch1 is disclosed. Methods and compositions for treating cancer using agents that inhibit the binding of GAS1, BOC and/or CDON to Ptch1 are also disclosed. Methods for identifying agents that may be used to inhibit Shh-mediated signalling/proliferation and cancer based on their capacity to inhibit the binding of GAS1, BOC and/or CDON to Ptch1 are also disclosed.
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