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Use of transforming growth factor-beta neutralizing antibodies and fusion proteins thereof in treating pain
Use of transforming growth factor-beta neutralizing antibodies and fusion proteins thereof in treating pain
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机译:转化生长因子-β中和抗体及其融合蛋白在治疗疼痛中的用途
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摘要
Provided herein are methods for treating pain and for reducing the excitability of nociceptors, comprising administering a TGF-β antagonist. In some embodiments, a TGF-β antagonist is a monoclonal TGF-β neutralizing antibody or a fusion product comprising a monoclonal TGF-β neutralizing antibody, a soluble receptor, an antisense oligodeoxynucleotides (ODNs), a ribozymes, a small inhibitory RNA (siRNA), Smad 6, Smad7, or a small molecule that blocks TGF-β signaling.
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