PLAQUE ARRAY METHODS AND COMPOSITIONS FOR FORMING AND DETECTING PLAQUES

摘要

Provided herein are methods and compositions for the in vitro formation of an array of plaque particles for use in biological assays, diagnosis, drug discovery and drug development. More specifically, the embodiments described herein relate to the in vitro synthesis of plaque particles when treated with biofluids and identification of such plaque particles by a variety of detection systems. In particular, the resulting in vitro plaque particles resemble atherosclerotic and amyloid plaques. The plaque embodiments described may be used to enable rapid, sensitive and/or efficient drug discovery, medical diagnostics and patient stratification.