Method for treating neurodegenerative disorders with oral dosage formulation containing both immediate-release and sustained-release drugs

摘要

Disclosed herein is a method for treating patient suffering from a disorder related to central nervous system with an oral dosage formulation that contains both sustained-release and immediate-release drugs. The sustained-release drug in the oral dosage formulation is memantine, and the formulation provides an average blood level C_max of the memantine in a range of about 10-24 ng/mL during an average T_max of about 10-45 hours. The immediate-release drug in the oral dosage formulation is an acetylcholinesterase inhibitor (AChEI), and the formulation provides an average blood level C_max of the AChEI in a range of about 12-38 ng/mL during an average T_max of less than about 4 hours.