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SYSTEMS MEDICINE PLATFORM FOR PERSONALIZED ONCOLOGY

机译:个性化肿瘤的系统医学平台

摘要

The present invention is directed to a platform (e.g., Web-based) that enables basic and clinical research activities by integrating patient characteristics and clinical outcome data with a variety of high-throughput research data in a unified environment. While several rich data repositories for high dimensional research data exist in the public domain, most focus on a single data type and do not support integration across multiple technologies. The present invention in at least one embodiment includes a broad collection of bioinformatics and systems biology tools for analysis and visualization of four major “omics” types: DNA, mRNA, microRNA, and metabolites, as well as next-generation sequencing. The present invention helps facilitate systems medicine by providing easy identification of trends and patterns in integrated datasets and hence facilitate the use of better targeted therapies for cancer.
机译:本发明针对一种平台(例如,基于Web的平台),该平台通过在统一环境中将患者特征和临床结果数据与各种高通量研究数据相集成来实现基础和临床研究活动。尽管在公共领域中存在一些用于高维研究数据的丰富数据存储库,但大多数存储库都集中在单个数据类型上,并不支持跨多种技术的集成。在至少一个实施方案中,本发明包括广泛的生物信息学和系统生物学工具,用于分析和可视化四种主要的“组学”类型:DNA,mRNA,microRNA和代谢产物,以及下一代测序。本发明通过在集成数据集中提供趋势和模式的容易识别来帮助促进系统医学,并因此促进使用针对癌症的更好的靶向疗法。

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