首页>
外国专利>
COMPOSITION AND METHOD FOR IMMUNOLOGICAL TREATMENT OF CANCER, PREVENTION OF CANCER RECURRENCE AND METASTASIS, AND OVERCOMING IMMUNE SUPPRESOR CELLS
COMPOSITION AND METHOD FOR IMMUNOLOGICAL TREATMENT OF CANCER, PREVENTION OF CANCER RECURRENCE AND METASTASIS, AND OVERCOMING IMMUNE SUPPRESOR CELLS
展开▼
机译:癌症的免疫治疗,预防癌症的复发和转移以及克服免疫支持细胞的组合物和方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Methods for the ex vivo generation of cells of the innate (NKT cells and NK cells) and adaptive (T cells) immune systems for use in adoptive cell transfer (ACT) are provided. The NKT cells render T cells resistant to immune suppression (e.g. they are resistant to the effects of myeloid-derived suppressor cells (MDSCs)). The method involves culturing disease-primed immune cells (obtained from a cancer patient or from a patient with an infectious disease) with i) byrostatin and ionomycin (B/I) to activate and differentiate the cells; followed by sequentially culturing the cells with a) a combination of IL-7 and IL-15 and then b) IL-2, to further differentiate the cells and to render them immune resistant. The resistant immune cells are used to treat and prevent cancer and infectious diseases.
展开▼