METHOD AND APPARATUS FOR IMAGE-BASED PREDICTION AND SORTING OF HIGH-PERFORMING CLONES

摘要

A method of predictive identification and separation of high-performing cells from a mixed population of cells includes distributing cells belonging to the mixed population to a plurality of open chambers; identifying open chambers containing desired cells and open chambers containing undesired cells; selectively sealing at least one open chamber containing undesired cells; and recovering the desired cells from the open chambers. Cells can be predictively assigned as desired or undesired based on an automated image analysis algorithm.