Embodiments of the invention include systems and methods for inferential generation of virtual sequencer controls in a MIDI sequencer to automate functionality of physical or virtual controls of MIDI instruments. MIDI source data from a song or a live feed is analyzed to determine a sequence of MIDI control commands from which a set of virtual sequencer controls can be automatically inferred without manual generation or configuration of the virtual control. The virtual sequencer controls are generated to automate a corresponding MIDI instrument control. Some embodiments provide functionality, including generation and handling of clone controls, use of virtual sequencer controls as slave and/or translation controls, and handling of after-click control information through a virtual synthesizers and the like.
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