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LIVE, ORAL VACCINE FOR PROTECTION AGAINST SHIGELLA DYSENTERIAE SEROTYPE 1
LIVE, ORAL VACCINE FOR PROTECTION AGAINST SHIGELLA DYSENTERIAE SEROTYPE 1
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机译:用于预防痢疾志贺氏菌1型痢疾的现场,口服疫苗
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摘要
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
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机译:本发明涉及伤寒沙门氏菌Ty21a,其包含核心连接的痢疾志贺氏菌血清型1O特异性多糖(O-Ps)和编码O抗原生物合成的DNA,所述DNA选自由以下组成的组:a)SEQ ID NO:1和2中任一项所示的DNA序列及其物种同源物; b)编码痢疾志贺氏菌血清型1多肽的DNA,该多肽由SEQ ID NOs:1和2中的任何一个编码,及其物种同源物; c)编码在中等严格条件下与(a)或(b)的DNA杂交的O抗原生物合成基因产物的DNA;以及相关序列,物质组成,疫苗,使用方法和制备方法。
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