首页> 外国专利> PHALERIA MACROCARPA EXTRACT, EXTRACTION PROCESS AND ITS USE AS CHOLESTERYL ESTER TRANSFERASE PROTEIN (CETP) INHIBITOR

PHALERIA MACROCARPA EXTRACT, EXTRACTION PROCESS AND ITS USE AS CHOLESTERYL ESTER TRANSFERASE PROTEIN (CETP) INHIBITOR

机译：HA提取物，提取过程及其作为胆固醇酯转移酶蛋白（CETP）抑制剂的用途

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摘要

An extract and/or herbal fraction and pharmaceutical preparation include extract of Phaleria macrocarpa which for the purpose of this invention, is referred to as DLBS1449. The herbal extract according to the teaching of this invention is effectively applicable to inhibit the expression and activity of Cholesteryl Ester Transferase Protein (CETP), increase HDL cholesterol level, decrease LDL cholesterol level without raising blood pressure therefore it is further applicable in atherosclerosis therapy.

机译：提取物和/或草药级分和药物制剂包括

Pheneria macrocarpa 的提取物，出于本发明的目的，其被称为DLBS1449。根据本发明的教导的草药提取物可有效地用于抑制胆固醇酯转移酶蛋白（CETP）的表达和活性，增加HDL胆固醇水平，降低LDL胆固醇水平而不升高血压，因此其进一步适用于动脉粥样硬化疗法。展开▼

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公开/公告号US2014099392A1

专利类型
公开/公告日2014-04-10

原文格式PDF
申请/专利权人 PT DEXA MEDICA;
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申请/专利号US201214111939
发明设计人 DWI ANGGUN SEPTIANA SUCIPTAN;ASEP ARIPIN;RAYMOND R. TJANDRAWINATA;
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申请日2012-04-19
分类号A61K36/83;A61K31/201;A61K45/06;A61K31/202;
国家 US
入库时间 2022-08-21 16:04:26

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3. Tag single nucleotide polymorphism rs1532624 located in cholesteryl ester transfer protein gene is associated with atherosclerosis cerebral ischemia [J] . Lin Huang, Dan-Xin Wang, Li-Min Zhou, 亚太热带医药杂志（英文版） . 2018,第004期

4. Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors [J] . Hiroshi Mabuchi, Atsushi Nohara, Akihiro Inazu Molecules and cells . 2014,第11期

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8. Characterization of an endogenous cytosolic protein inhibitor (CIP-28) of cytosolic rat testicular neutral cholesteryl ester hydrolase. [D] . Hines, Denise Somers. 1997

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