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Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof

机译:苯基嘧啶酮化合物,药物组合物,制备方法和用途

摘要

The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof and to the pharmaceutical composition as well as the preparation method of the compounds. The compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like.; embedded image
机译:本发明涉及一类苯基嘧啶酮化合物,药物组合物,其制备方法及其用途。更具体地,本发明涉及一种下式I的苯基嘧啶酮化合物,其药学上可接受的盐或溶剂化物,并且涉及药物组合物以及该化合物的制备方法。本发明的式I化合物可有效抑制V型磷酸二酯酶(PDE5),因此可用于治疗各种血管疾病,例如男性勃起功能障碍,肺动脉高压等。 “嵌入式图像”

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