its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula I are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable."/>
公开/公告号US8853243B2
专利类型
公开/公告日2014-10-07
原文格式PDF
申请/专利号US201113111426
申请日2011-05-19
分类号A61K31/445;C07D241/04;
国家 US
入库时间 2022-08-21 16:02:02