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Method of screening for an agent for treating arthritis and promoting growth of articular chondrocytes

机译:筛选用于治疗关节炎和促进关节软骨细胞生长的药剂的方法

摘要

This invention provides a new therapeutic or prophylactic agent for arthritis such as osteoarthritis. Specifically, it provides a therapeutic or prophylactic agent for arthritis such as osteoarthritis, or an agent for promoting the growth of articular chondrocyte, comprising a guanyl cyclase B (GC-B) activator as an active ingredient; or a method for inhibiting arthritis or for promoting the growth of articular chondrocyte by activating GC-B; or a method for screening an agent for promoting the growth of articular chondrocyte or an agent capable of treating arthritis using the GC-B activity as an indication.
机译:本发明提供了一种用于关节炎例如骨关节炎的新的治疗或预防剂。具体而言,它提供了以鸟苷酸环化酶B(GC-B)激活剂为有效成分的骨关节炎等关节炎的治疗剂或预防剂,或关节软骨细胞的生长促进剂。或通过激活GC-B来抑制关节炎或促进关节软骨细胞生长的方法;或以GC-B活性为指标来筛选促进关节软骨细胞生长的试剂或能够治疗关节炎的试剂的方法。

著录项

  • 公开/公告号US8658373B2

    专利类型

  • 公开/公告日2014-02-25

    原文格式PDF

  • 申请/专利权人 KAZUWA NAKAO;HIDETOMO KITAMURA;

    申请/专利号US20090623936

  • 发明设计人 KAZUWA NAKAO;HIDETOMO KITAMURA;

    申请日2009-11-23

  • 分类号G01N33/53;C07K14/705;

  • 国家 US

  • 入库时间 2022-08-21 16:00:07

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