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Triggered covalent probes for imaging and silencing genetic expression
Triggered covalent probes for imaging and silencing genetic expression
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机译:触发共价探针,用于成像和沉默基因表达
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摘要
The present invention relates to the use of cross-linking probes to covalently bind probes to nucleic acid targets. In some embodiments, the probe comprises an initiator region that is able to bind to a first portion of a target nucleic acid, a probe region linked too the initiator region that is able to bind to a second region of the target nucleic acid and that comprises one or more cross-linkers, and a blocking region hybridized to the probe region.
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