Procedure for Enzymatic Synthesis of acid (7S) - 3 - 4 - dimetoxibiciclo 4.2.0 octa - 1,3,5 - triennium 2008-2010 - 7 - carboxylic acid or its esters, and their application to the synthesis of Ivabradine and its Salts

摘要

1. Characteristic 1: procedure for synthesis of pure optical formula compound (1): through electrolytic disinfection of coccic acid or pure non optimal formula enzyme (2),by means of a lipase or an esterase, in a mixture of ROH alcohol, in which R represents a linear or branched C₁₋₆ alkyl group, and of an organic cosolvent, at a concentration of 5 to 500 g / L of compound of formula ( 2) per liter of solvent mixture, in an I / O ratio of 10/1 to 1/100, at a temperature of 25ºC to 40ºC.