The basic composition of berberine and / or at least one of its derivatives, in combination the nanopartu00cdculas gold, its process of obtaining and Its Applications

摘要

Composition based on berberine and / or at least one of its derivatives, in qassociau00c7u00c3o the nanopartu00cdculas gold, its process of obtaining and its applications. The present invention relates to a composition comprising at least one nanoestruturado system based on combination of barberina and / or at least one of its derivatives on gold nanoparticles modified on the surface.This composition is useful in the preparation of products for biological application, especially in the treatment of vascular diseases.The surface modification carried out preferably by at least a substance with the mercapto group in its structure, promotes the stabilization of the particles in the size nanomu00e9ricas, preventing the agglomeration of drug molecules in aqueous and organic media.What can also carry a large number of molecules when compared with the nanopartu00edcula devoid of surface modification.Another method of the invention is an association of the substance vasdilatadora with gold nanopartu00edcula modifies surface functioning as a delivery system targeted drugs (drug delivery), thus avoiding the vasodilator substance can be released from the form L Ivre in target system in concentrations exceeding and act in an indiscriminate manner.