1. Using 4,4-dimethyl-3,5,8-trichlorocyanide 5.1.0 octabromodiphenyl ether and lithium chloride to 1,4-dimethyl-3,5Isopropanol; and polymorphic monohydrate I caffeine.

摘要

Preparation Process of high purity of gadobutrol, from cicleno 1,4,7,10-tetraazacyclododecane (4.4 - dimethyl - trioxabiciclo 3,5,8 5.1.0 [] octane and Lithium chloride in alcohol; polymorphic Form I Monohydrate of gadobutrol; Parental and its use in a formulation useful as Contrast.