1. Inhibitors from helix-1.3-oxalic acid and helix-1.4-oxalic acid, Bac 1 and/or Bac2; pharmacological synthesis; preparatory procedures; and uses for the treatment and/or prevention of Alzheimer's disease and diabetes.

摘要

The present invention provides spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.